What is the most appropriate antibiotic regimen for a patient with mild non-purulent cellulitis?

In cases of mild non-purulent cellulitis, the focus of antibiotic therapy is typically on beta-hemolytic streptococci and Staphylococcus aureus, particularly when the infection is uncomplicated. Cephalexin is a first-generation cephalosporin that provides excellent coverage against these organisms. Its spectrum of activity includes streptococci, which are the most common pathogens in mild cellulitis cases.

The dosing regimen of cephalexin at 500 mg orally every 6 hours ensures adequate levels of the medication in the body to effectively combat the infection. This frequency is ideal for maintaining therapeutic levels, especially in infections caused by rapidly dividing organisms.

While other options such as clindamycin, doxycycline, and amoxicillin have their mechanisms of action and can be effective in certain scenarios, cephalexin is specifically preferred in this context due to its targeted coverage and established efficacy in treating mild non-purulent cellulitis. Clindamycin may be more appropriate for patients allergic to penicillin or in cases where coverage for anaerobes is needed, while doxycycline is generally used for more atypical infections. Amoxicillin, while effective against some streptococci, may not provide the