What is a common first-line treatment for severe allergic reactions besides epinephrine?

Diphenhydramine, an antihistamine, is commonly used as a first-line treatment for severe allergic reactions alongside epinephrine. After the initial administration of epinephrine, which acts quickly to counteract life-threatening symptoms such as airway swelling and hypotension, diphenhydramine can help alleviate additional allergic symptoms, such as urticaria (hives), pruritus (itching), and nasal congestion. It works by blocking histamine H1 receptors, thus reducing the effects of histamine release that occur during an allergic reaction.

Using diphenhydramine can be essential for managing symptoms that continue or emerge after epinephrine administration, especially when patients are observed for anaphylactic reactions in a clinical setting. However, it’s important to note that diphenhydramine does not replace the need for epinephrine, which remains the primary and most crucial treatment for anaphylaxis.

While corticosteroids can be administered after initial management with epinephrine and antihistamines to address delayed reactions and reduce inflammation, they do not have an immediate effect and are not used as the first line in the acute treatment phase. Aspirin is not an appropriate choice for allergic reactions, as it may exacerbate certain types of allergic